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Sapitinib

Sapitinib structure

CAS No:
848942-61-0
Formula:
C23H25ClFN5O3
Chemical Name:
Sapitinib
Synonyms:
1-Piperidineacetamide,4-[[4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-methyl-;4-[[4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-methyl-1-piperidineacetamide;4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline;AZD 8931;Sapitinib;Sapatinib;2-[4-[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-N-methylacetamide
Categories:
Biochemical Engineering > Inhibitors

Description

Sapitinib (AZD-8931) is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.

Sapitinib Basic Attributes

Molecular Weight：

473.9277032

Exact Mass：

473.93

EC Number：

-0

Characteristics

PSA：

88.6

XLogP3：

Density：

1.3±0.1 g/cm3

Boiling Point：

632.8±55.0°C at 760 mmHg

Flash Point：

336.5±31.5 °C

Refractive Index：

1.627

Safety Information

Precautionary statement(s)：

P201, P202, P260, P264, P270, P281, P301+P312, P308+P313, P314, P330, P405, P501

Hazard Statements：

H302

Sapitinib Use and Manufacturing

AZD8931 is a novel potent reversible small molecule epidermal growth factor receptor, ERBB2 (HER2) and ERBB3 inhibitor with an IC50 of 4, 3, 4 nM, respectively.

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AZD8931

CAS No.: 848942-61-0

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