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AZD8931

AZD8931 structure

CAS No:
848942-61-0
Formula:
C23H25ClFN5O3
Chemical Name:
AZD8931
Synonyms:
2-[4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-N-methylacetamide;AZD8931, >=96%;AZD8931 (SAPITINIB);AZD 8931;4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quina;AZ08931 2-(4-(4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-N-methylacetamide;2-(4-(4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-N-methylacetamide;Sapitinib(AZD8931);AZD8931
Categories:
Biochemical Engineering > Inhibitors

Description

Sapitinib (AZD-8931) is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.

ChEBI: A member of the class of quinazolines that is 4-amino-7-methoxyquinazoline in which the amino group has been substituted by a 3-chloro-2-fluorophenyl group and in which position 6 of the quinoline ring has been substituted by a {1-[2-(methylamino)-2-oxoeth l]piperidin-4-yl}oxy group. Sapitinib is a dual tyrosine kinase inhibitor (TKI) of epithelial growth factor receptors (EGFR) HER2 and HER3.

AZD8931 Basic Attributes

Molecular Weight：

473.93

Exact Mass：

473.93

Color/Form：

White to off-white

Characteristics

PSA：

88.6

XLogP3：

Density：

1.339

Boiling Point：

632.8±55.0 °C(Predicted)

Flash Point：

336.5±31.5 °C

Refractive Index：

1.627

PKA：

16.17±0.46(Predicted)

Critical Temperature & Pressure：

Store at -20°C

Safety Information

Precautionary statement(s)：

P201, P202, P260, P264, P270, P281, P301+P312, P308+P313, P314, P330, P405, P501

Hazard Statements：

H302

AZD8931 Use and Manufacturing

AZD8931 is a novel potent reversible small molecule epidermal growth factor receptor, ERBB2 (HER2) and ERBB3 inhibitor with an IC50 of 4, 3, 4 nM, respectively.

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AZD8931

CAS No.: 848942-61-0

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