 Home > Encyclopedia > Pelitinib

Pelitinib

Pelitinib structure

CAS No:
257933-82-7
Formula:
C24H23ClFN5O2
Chemical Name:
Pelitinib
Synonyms:
2-Butenamide,N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-,(2E)-;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;EKB 569;WAY-EKB 569;Pelitinib
Categories:
Biochemical Engineering > Inhibitors

Description

Pelitinib (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively.

Pelitinib Basic Attributes

Molecular Weight：

467.93

Exact Mass：

467.92

EC Number：

1312995-182-4

Characteristics

PSA：

90.3

XLogP3：

4.5

Appearance：

white to beige

Density：

1.3±0.1 g/cm3

Melting Point：

173-178°C

Boiling Point：

655.5°C at 760 mmHg

Flash Point：

350.2±31.5 °C

Refractive Index：

1.645

Water Solubility：

DMSO: soluble5mg/mL, clear (warmed)

Storage Conditions：

-20°C Freezer

Vapor Pressure：

4.64E-17mmHg at 25°C

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

safety instructions：

Marks：

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

Pelitinib Use and Manufacturing

Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.

Recommended Suppliers of Pelitinib

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Pelitinib

CAS No.: 257933-82-7

Content: 99.00%

Inquiry
Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

Pelitinib(EKB-569)

CAS No.: 257933-82-7

Content: 99%

Inquiry