 Home > Encyclopedia > 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1)

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1)

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1) structure

CAS No:
131740-09-5
Formula:
C21H20ClNO5.ClH
Chemical Name:
4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1)
Synonyms:
4H-1-Benzopyran-4-one,2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-,hydrochloride (1:1);4H-1-Benzopyran-4-one,2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-,hydrochloride,cis-(-)-;4H-1-Benzopyran-4-one,2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-,hydrochloride;NSC 649890;HL 275 hydrochloride;Alvocidib hydrochloride;MDL 107826A;L 868275 hydrochloride;HMR 1275 hydrochloride;L 86-8275 hydrochloride;2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride;Flavopiridol hydrochloride
Categories:
Biochemical Engineering > Inhibitors

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Description

Yellow PowderChEBI: A hydrochloride salt resulting from the formal reaction of equimolar amounts of alvocidib and hydrogen chloride. A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic p aque formation.

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1) Basic Attributes

Molecular Weight：

438.3

Exact Mass：

437.079681

EC Number：

1592732-453-0

Characteristics

PSA：

90.2

Appearance：

white to light brown

Melting Point：

169.5-170°C

Flash Point：

318.8ºC

Water Solubility：

H2O: ~2mg/mL

Storage Conditions：

2-8°C

Specific rotation：

24D -1.73 to -3.9°

Safety Information

wgk germany：

hazard class code：

RTECS Number：

DJ2978830

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1) Use and Manufacturing

An inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells

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Flavopiridol hydrochloride

CAS No.: 131740-09-5

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Guide of 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1)

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
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4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1)

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