MK 2206 dihydrochloride
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MK 2206 dihydrochloride
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CAS No:
1032350-13-2
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Formula:
C25H21N5O.2ClH
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Chemical Name:
MK 2206 dihydrochloride
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Synonyms:
1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one,8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-,hydrochloride (1:2);MK 2206 dihydrochloride
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CAS No:
Description
MK 2206 is an orally active allosteric Akt inhibitor with IC50s of 5, 12 and 65 nM for Akt1, Akt2 and Akt3, respectively.
MK 2206 dihydrochloride Use and Manufacturing
AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents.
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