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TAE226 (NVP-TAE226)

TAE226 (NVP-TAE226) structure

CAS No:
761437-28-9
Formula:
C23H25ClN6O3
Chemical Name:
TAE226 (NVP-TAE226)
Synonyms:
NVP-TAE 226;TAE226;TAE226 (NVP-TAE226);2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide;Benzamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-;NVP-TAE 226 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide;2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide
Categories:
Biochemical Engineering > Inhibitors

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Description

NVP-TAE 226 is a dual tyrosine kinase inhibitor of FAK (IC50=5.5 nM) and IGF-IR (mean IC50=0.14 μM).

2-[[5-chloro-2-[2-methoxy-4-(4-morpholinyl)anilino]-4-pyrimidinyl]amino]-N-methylbenzamide is a member of morpholines.

TAE226 (NVP-TAE226) Basic Attributes

Molecular Weight：

468.936

Exact Mass：

468.167664

DSSTox ID：

DTXSID90433025

HScode：

2934999090

Characteristics

PSA：

101

XLogP3：

4.1

Density：

1.3±0.1 g/cm3

Refractive Index：

1.659

Drug Information

MeSH Entry Terms：

TAE226

Computed Properties

Molecular Weight:468.9
XLogP3:4.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:468.1676664
Monoisotopic Mass:468.1676664
Topological Polar Surface Area:101
Heavy Atom Count:33
Complexity:625
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes