2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one
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![2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/1a99970c340b4bc98e61225a7c60162b.png "2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one")
2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one
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CAS No:
154447-35-5
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Formula:
C17H15NO3
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Chemical Name:
2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one
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Synonyms:
4H-Naphtho[1,2-b]pyran-4-one,2-(4-morpholinyl)-;2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one;LY 293646;NU 7026;2-Morpholin-4-ylbenzo[h]chromen-4-one
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CAS No:
Description
NU 7026 is a novel specific DNA-PK inhibitor with IC50 of 0.23±0.01 μM, also inhibits PI3K with IC50 of 13±3 μM.
Characteristics
38.8
2.8
tan solid
1.33
267-269 °C @ Solvent: Methanol, Water
459.9±45.0 °C(Predicted)
231.9±28.7 °C
1.673
DMSO: 3 mg/mL at 60 °C, soluble
2-8°C
2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one Use and Manufacturing
ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC 50 values are 0.23, 13.0, > 100 and > 100 μ M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.
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2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one
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