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BI-97C1

BI-97C1 structure

CAS No:
1228108-65-3
Formula:
C42H40N2O8
Chemical Name:
BI-97C1
Synonyms:
BI-97C1;Sabutoclax;(1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'-binaphthalene]-5,5'-dicarboxamide;[2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-, (1R)
Categories:
Biochemical Engineering > Inhibitors

Description

Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.

BI-97C1 Basic Attributes

Molecular Weight：

700.7756

Exact Mass：

700.278442

DSSTox ID：

DTXSID20153724

Characteristics

PSA：

180

XLogP3：

8.9

Density：

1.4±0.1 g/cm3

Flash Point：

501.7±34.3 °C

Refractive Index：

1.713

Drug Information

MeSH Entry Terms：

1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5-(2-phenylpropyl)-N5'-(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide

BI-97C1 Use and Manufacturing

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

Computed Properties

Molecular Weight:700.8
XLogP3:8.9
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:700.27846624
Monoisotopic Mass:700.27846624
Topological Polar Surface Area:180
Heavy Atom Count:52
Complexity:1100
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Sabutoclax

CAS No.: 1228108-65-3

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