ABT 263
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ABT 263
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CAS No:
923564-51-6
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Formula:
C47H55ClF3N5O6S3
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Chemical Name:
ABT 263
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Synonyms:
Benzamide,4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-;4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide;ABT 263;Navitoclax;A 855071.0;1000696-69-4
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CAS No:
Description
Navitoclax (ABT-263) is a potent and oral Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.
Characteristics
170
9.6
pale yellow solid
1.4±0.1 g/cm3
114-116°C
1.655
-20°C Freezer, Under Inert Atmosphere
ABT 263 Use and Manufacturing
A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.
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