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Camostat mesylate

Camostat mesylate structure

CAS No:
59721-29-8
Formula:
C20H22N4O5.CH4O3S
Chemical Name:
Camostat mesylate
Synonyms:
Benzeneacetic acid,4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-,2-(dimethylamino)-2-oxoethyl ester,methanesulfonate (1:1);Benzeneacetic acid,4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-,2-(dimethylamino)-2-oxoethyl ester,monomethanesulfonate;FOY 305;Camostat mesylate;FOY-S 980;Foipan;Camostat monomethanesulfonate
Categories:
Biochemical Engineering > Inhibitors

Description

Camostat Mesylate(FOY305; FOY-S980) is a trypsin-like protease inhibitorTarget: Trypsin-like proteaseCamostat mesilate (500 mM) inhibits generation of TGF-beta by suppressing plasmin activity and reduces the activity of TGF-beta, which blocks in vitro activation of HSCs [1]. Camostat mesilate (20 mM) combined with insulin results a significant hypoglycemic effect following large intestinal administration. Camostat mesilate (20 mM) is effective in reducing insulin degradation in both smal

Camostat mesylate Basic Attributes

Molecular Weight：

494.52

Exact Mass：

494.147125

EC Number：

1806241-263-5

Characteristics

PSA：

200

XLogP3：

2.84290

Appearance：

white to tan

Melting Point：

150-155 °C

Boiling Point：

634.6ºC at 760 mmHg

Water Solubility：

soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).

Storage Conditions：

Desiccate at RT

Safety Information

Packing level：

Ⅲ

Hazard category：

Transport codes：

UN 3077 9 / PGIII

wgk germany：

hazard class code：

36/37/38-50

safety instructions：

26-61

RTECS Number：

CY1571620

Marks：

Xi,N

Precautionary statement(s)：

P261-P273-P305 + P351 + P338

Hazard Statements：

H315-H319-H335-H400

Camostat mesylate Use and Manufacturing

Orally active, non-peptide proteolitic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate. Protease inhibitor

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