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GW788388

GW788388 structure

CAS No:
452342-67-5
Formula:
C25H23N5O2
Chemical Name:
GW788388
Synonyms:
4-[4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl]-N-(tetrahydropyran-4-yl)benzamide;GW 788388;BenzaMide, 4-[4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-;4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide;N-(oxan-4-yl)-4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}benzaMide;GW 788388 4-[4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl]-N-(tetrahydropyran-4-yl)benzamide;GW 788388, >=98%
Categories:
Biochemical Engineering > Inhibitors

Description

GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor.

GW788388 Basic Attributes

Molecular Weight：

425.48242

Exact Mass：

425.185181

UNII：

N14114957J

DSSTox ID：

DTXSID70196444

HScode：

2934999090

Characteristics

PSA：

92.8

XLogP3：

2.7

Density：

1.3±0.1 g/cm3

Flash Point：

367.0±31.5 °C

Refractive Index：

1.680

Drug Information

MeSH Entry Terms：

4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide

GW788388 Use and Manufacturing

GW788388 is a new TGF-beta type I receptor inhibitor with a much improved pharmacokinetic profile compared with SB431542.

Computed Properties

Molecular Weight:425.5
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:425.18517499
Monoisotopic Mass:425.18517499
Topological Polar Surface Area:92.8
Heavy Atom Count:32
Complexity:605
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes