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SUBSTANCE P

SUBSTANCE P structure

CAS No:
33507-63-0
Formula:
C63H98N18O13S
Chemical Name:
SUBSTANCE P
Synonyms:
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET;H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE);SUBSTANCE P BOVINE;SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11];SUBSTANCE P (TYR8);SUBSTANCE P
Categories:
Biochemical Engineering > Polypeptide

Description

Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). Sequence: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.

An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.

SUBSTANCE P Basic Attributes

Molecular Weight：

1347.63

Exact Mass：

1346.728149

EC Number：

251-545-8

UNII：

675VGV5J1D

Characteristics

PSA：

544

XLogP3：

-0.85

Appearance：

white powder

Density：

1.4±0.1 g/cm3

Melting Point：

148 °C

Refractive Index：

1.663

Water Solubility：

soluble in water, DMSO, and Acetic Acid.H2O: 1 mg/mL

Storage Conditions：

−20°C

Collision Cross Section：

399.88 Å² [M+2H]2+ [CCS Type: DT, Method: stepped-field]|495.74 Å² [M+3H]3+ [CCS Type: DT, Method: stepped-field]|362.51 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|400 Å² [M+2H]2+

Safety Information

wgk germany：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. (See all compounds classified as Neurotransmitter Agents.)

MeSH Entry Terms：

Euler Gaddum Substance P

SUBSTANCE P Use and Manufacturing

Methods of Manufacturing

The bovine hypothalamus is used as raw material, homogenized in acetone and hydrochloric acid solution, filtered and extracted with petroleum ether, and purified by column chromatography and paper electrophoresis.

Uses

It is used in biochemical research. It is used as a vasodilator and nerve-tuning agent in medicine. It can promote saliva secretion, increase capillary permeability, can cause smooth muscle contraction, lower blood pressure, and stimulate secretory tissues. It can transmit pain.

Computed Properties

Molecular Weight:1347.6
XLogP3:-2.3
Hydrogen Bond Donor Count:15
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:42
Exact Mass:1346.72814643
Monoisotopic Mass:1346.72814643
Topological Polar Surface Area:544
Heavy Atom Count:95
Complexity:2620
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Learn More Other Chemicals

Substance P (5-11), arginyl(5)-tryptophan(7,9)-

85077-79-8
substance P (4-11),prolyl(4)-tryptophyl(7,9)-leucinamide(11)-

87026-40-2
(CYS3,6,TYR8,PRO9)-SUBSTANCE P

141459-28-1
EsoMeprazole related substance H193/61 Formula

784143-42-6
substance P (6-11), Glu(Glc)(6)- Formula

128022-96-8
substance P (6-11), arginyl(6)-tryptophyl(7,9)-methylphenylalanine(8)- Formula

129244-81-1
substance P (5-11), N-alpha-(desamino-3-iodotyrosyl)- 8-N-methylphenylalanine-5,6-asparagine- Structure

104499-96-9
substance P (6-11), N(alpha)-(3-iododesaminotyrosyl)- Structure

97207-37-9
What is Substance P, C-terminal glycine extended

98093-85-7
What is (D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P

77275-70-8

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Guide of SUBSTANCE P

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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SUBSTANCE P

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