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Bisdemethoxycurcumin

Bisdemethoxycurcumin structure

CAS No:
33171-05-0
Formula:
C19H16O4
Chemical Name:
Bisdemethoxycurcumin
Synonyms:
1,6-Heptadiene-3,5-dione,1,7-bis(4-hydroxyphenyl)-,(1E,6E)-;1,6-Heptadiene-3,5-dione,1,7-bis(p-hydroxyphenyl)-,(E,E)-;(1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione;Bisdemethoxycurcumin;Curcumin III;Didemethoxycurcumin;Bisdesmethoxycurcumin;(1E,6E)-Bis(demethoxy)curcumin;104024-29-5;22608-12-4;85801-92-9;91884-88-7
Categories:
Cosmetic Ingredient > Antioxidant Ingredient

Description

Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.IC50 value:Target: Anticancer natural compoundin vitro: BDMC-induced apoptosis was mediated by a combinatory inhibition of cytoprotective proteins, such as Bcl2 and heme oxygenase-1 and increased generation of reactive oxygen species. Intriguingly, BDMC-induced apoptosis was reversed with co-treatment of sr144528, a cannabinoid receptor (CBR) 2 ant

Solid

Bisdemethoxycurcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups. It has a role as a metabolite and an EC 3.2.1.1 (alpha-amylase) inhibitor. It is a beta-diketone, a polyphenol, an enone and a diarylheptanoid. It derives from a 4-coumaric acid.

Bisdemethoxycurcumin Basic Attributes

Molecular Weight：

308.33

Exact Mass：

308.33

EC Number：

1312995-182-4

UNII：

2EFO1BP34R

NSC Number：

687839

DSSTox ID：

DTXSID00872663

HScode：

29145090

Characteristics

PSA：

74.6

XLogP3：

3.3

Density：

1.3±0.1 g/cm3

Melting Point：

224 °C

Boiling Point：

551.3°C at 760 mmHg

Flash Point：

301.3±25.2 °C

Refractive Index：

1.680

Water Solubility：

32.69 mg/L @ 25 °C (est)

Vapor Pressure：

9.17E-13mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

Metabolism/Metabolites：

Bisdemethoxycurcumin has known human metabolites that include Bisdemethoxycurcumin, 4-O-glucuronide.

MeSH Entry Terms：

bis(4-hydroxycinnamoyl)methane

Bisdemethoxycurcumin Use and Manufacturing

Bisdemethoxycurcumin is one of the three major forms of curcuminoids found in the rhizomes of turmeric. Bisdemethoxycurcumin displays antioxidant, anti-inflammatory as well as chemotherapeutic activity. Bisdemethoxycurcumin acts as an inhibitor of human pancreatic α-amylase, a target for type-2 diabetes .

Computed Properties

Molecular Weight:308.3
XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:308.10485899
Monoisotopic Mass:308.10485899
Topological Polar Surface Area:74.6
Heavy Atom Count:23
Complexity:408
Defined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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33171-05-0 (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

CAS No.: 33171-05-0

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Guide of Bisdemethoxycurcumin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Bisdemethoxycurcumin

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