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Isoamyl p-methoxycinnamate

Isoamyl p-methoxycinnamate structure

CAS No:
71617-10-2
Formula:
C15H20O3
Chemical Name:
Isoamyl p-methoxycinnamate
Synonyms:
2-Propenoic acid,3-(4-methoxyphenyl)-,3-methylbutyl ester;4-Methoxycinnamic acid isoamyl ester;Isoamyl p-methoxycinnamate;Neo Heliopan E 1000;Isopentyl 4-methoxycinnamate;Neo Heliopan 1000;Isoamyl 4-methoxycinnamate;Amiloxate;E 1000;Isoamyl methoxycinnamate;4-Methoxycinnamic acid 2-isoamyl ester;NSC 408332;Isopentyl p-methoxycinnamate;4-Methoxycinnamic acid isopentyl ester;3-Methylbutyl 3-(4-methoxyphenyl)prop-2-enoate
Categories:
Cosmetic Ingredient > Light Stabilizer

Description

Light yellow viscous liquid

Amiloxate is a cinnamate ester.|Amiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m. It is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate. Amiloxate is a cinnamic acid derivative with an anti-inflammatory activity.

Isoamyl p-methoxycinnamate Basic Attributes

Molecular Weight：

248.32

Exact Mass：

248.32

EC Number：

275-702-5

UNII：

376KTP06K8

NSC Number：

408332

DSSTox ID：

DTXSID1046055

HScode：

2918990090

Characteristics

PSA：

35.53000

XLogP3：

4.06

Density：

1.0±0.1 g/cm3

Melting Point：

< -30

Boiling Point：

158°C/0.7mmHg(lit.)

Flash Point：

151.6±15.5 °C

Refractive Index：

1.524

Water Solubility：

Insoluble

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

UD3393500

Hazard Statements：

H413

GHS Classification：

|Warning|H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501|Aggregated GHS information provided by 39 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity Summary：

Oral LD50 in rat is 9600 mg/kg [MSDS].

Protein Binding：

No pharmacokinetic data available.

Drug Information

Drug Indication：

Indicated as an active sunscreen agent.

Pharmacology：

In a mouse study, amiloxate exerted a dose-dependent anti-inflammatory action and inhibited edema by about 70% even at a low dose. Due to structural similarities, amiloxate may also display antioxidant and antimicrobial properties of cinnamic acid.

Absorption：

According to _in vitro_ studies of amiloxate-containing tape strips on porcine ear, there was no detection of amiloxate undergoing skin penetration.|No pharmacokinetic data available.

Metabolism/Metabolites：

No pharmacokinetic data available.

Biological Half-Life：

No pharmacokinetic data available.

Mechanism of Action：

Amiloxate is a UV-B filter that selectively absorbs UV-B rays. It is proposed that amiloxate mediates an antioxidant action by acting as a free radical scavenger.

MeSH Entry Terms：

3-(4-methoxyphenyl)-2-propenoic acid 3-methylbutyl ester

Isoamyl p-methoxycinnamate Use and Manufacturing

Uses

Isoamyl 4-Methoxycinnamate is used in the highly protective sunscreen composition against the UVA/UVB.

Use Classification：

Cosmetics -> Uv absorber; Uv filter

Computed Properties

Molecular Weight:248.32
XLogP3:3.9
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:248.14124450
Monoisotopic Mass:248.14124450
Topological Polar Surface Area:35.5
Heavy Atom Count:18
Complexity:263
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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IsoaMyl 4-MethoxycinnaMate71617-10-2

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CAS No.: 71617-10-2

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Isopentyl-4-Methoxycinnamate 95.0% Light yellow viscous liquid HANDOM CHEM

CAS No.: 71617-10-2

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Content: 95.0%

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Guide of Isoamyl p-methoxycinnamate

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Isoamyl p-methoxycinnamate

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