lithospermic acid B
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lithospermic acid B
structure -
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CAS No:
121521-90-2
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Formula:
C36H30O16
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Chemical Name:
lithospermic acid B
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Synonyms:
3-(1-Carboxy-2-(3,4-dihydroxyphenyl)ethyl) 4-(3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylate (2S-(2alpha,3beta(S*),4(E(S*))))-;3-Benzofurancarboxylic acid, 4-(3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-, 3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethyl) ester, (2S-(2alpha,3beta(S*),4(E(S*))))-;Lithospermic acid B;SALVIANOLIC ACID B;LITHOSPERMIC ACID B;DANFENSUAN B;(2S,3S)-4-[(1E)-3-[(1R)-1-Carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxo-1-propen-1-yl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylic acid 3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl] ester;Salvianolic Acid B (25 mg);Salvianolic acid B, 98%, from Salvia miltiorrhiza;Salvianolic acid B, froM Salvia Miltiorrhiza
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CAS No:
Description
Yellow Solid
ChEBI: Salvianolic acid B is a member of the class of 1-benzofurans that is an antioxidant and free radical scavenging compound extracted from S. miltiorrhiza It has a role as a plant metabolite, an anti-inflammatory agent, an antioxidant, a hypoglycemic agent, an osteogenesis regulator, an apoptosis inducer, a hepatoprotective agent, a neuroprotective agent, a cardioprotective agent, an autophagy inhibitor, an antidepressant and an antineoplastic agent. It is a polyphenol, a member of 1-benzofurans, an enoate ester, a dicarboxylic acid and a member of catechols.
Salvianolic acid B is one of the main water soluble bioactive components ofSalvia miltiorrhizamedicinal plant, the root of which is used in the treatment of dysmenorrhea, coronary heart disease, chronic renal failure, cerebrovascular disease, hypertension, and cytotoxicity against human tumor cell lines.
Characteristics
278.04000
3.33450
white to tan
1.637±0.06 g/cm3(Predicted)
98-110°C
1020.3±65.0 °C(Predicted)
322.1±27.8 °C
1.739
H2O: ≥5mg/mL
-20°C Freezer
0mmHg at 25°C
2.77±0.10(Predicted)
-20°C
lithospermic acid B Use and Manufacturing
Salvianolic acid A (Sal A) and salvianolic acid B (Sal B) were isolated and purified from the crude extract of Salvia miltiorrhiza. Antioxidant activities of Sal A and Sal B were also evaluatedhe ABTS results showed that Sal A and Sal B exhibited high total antioxidant activities, their EC50 values were 1.350.00 and 1.430.01 .mu.g/mL.
Computed Properties
Molecular Weight:718.6
XLogP3:4
Hydrogen Bond Donor Count:9
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:14
Exact Mass:718.15338487
Monoisotopic Mass:718.15338487
Topological Polar Surface Area:278
Heavy Atom Count:52
Complexity:1290
Defined Atom Stereocenter Count:4
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Scavenges free radicals to protect myocardial cells
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