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α-Chaconine

α-Chaconine structure

CAS No:
20562-03-2
Formula:
C45H73NO14
Chemical Name:
α-Chaconine
Synonyms:
β-D-Glucopyranoside,(3β)-solanid-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-;α-Chaconine;Solanidane,β-D-glucopyranoside deriv.;1H-Naphth[2′,1′:4,5]indeno[1,2-b]indolizine,β-D-glucopyranoside deriv.;(3β)-Solanid-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside;Chaconine;1192476-64-4
Categories:
Natural Products > Alkaloids

Description

α-Chaconine, isolated from a Solanum tuberosum L. cv Jayoung, inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects[1].

Alpha-Chaconine is a steroid saponin.

α-Chaconine Basic Attributes

Molecular Weight：

852.06

Exact Mass：

852.06

UNII：

5QOL0LIM81

Characteristics

PSA：

220.46000

XLogP3：

1.12070

Density：

1.37 g/cm3

Melting Point：

243 °C

Refractive Index：

1.621

Water Solubility：

pyridine: 10 mg/mL, clear, very faintly yellow

Storage Conditions：

−20°C

Toxicity：

Peritoneal-rat LD50: 84 mg/kg; peritoneal-mouse LD50: 19 mg/kg

Flammability characteristics：

Thermal decomposition spicy irritating smoke

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

1544

wgk germany：

hazard class code：

safety instructions：

22-36/37

RTECS Number：

FL6700000

Marks：

Storage features：

The warehouse is low-temperature, ventilated and dry; stored separately from food materials

GHS Classification：

|Warning|H361 (97.56%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH Entry Terms：

alpha-chaconine

α-Chaconine Use and Manufacturing

Use Classification：

Food Contaminant -> NATURALLY_OCCURRING_TOXICANT; -> JECFA Functional Classes

Food Additive Classes：

Food Contaminant -> NATURALLY_OCCURRING_TOXICANT;

Computed Properties

Molecular Weight:852.1
XLogP3:1.8
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:7
Exact Mass:851.50310600
Monoisotopic Mass:851.50310600
Topological Polar Surface Area:221
Heavy Atom Count:60
Complexity:1570
Defined Atom Stereocenter Count:26
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 20562-03-2

Grade: Industrial Grade

Content: 99%

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Guide of α-Chaconine

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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α-Chaconine

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