2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol]
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![2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/d67aee10a934498cb67dec42517e8448.png "2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol]")
2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol]
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CAS No:
103597-45-1
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Formula:
C41H50N6O2
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Chemical Name:
2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol]
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Synonyms:
Phenol,2,2′-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-;2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol];2,2′-Methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazolylphenol];Mark LA 31;Mixxim BB 100;ADK Stab LA 31;LA 31;2,2′-Methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-(2H-benzotriazol-2-yl)phenol];Tinuvin 360;2,2′-Methylenebis[6-(2-benzotriazolyl)-4-(1,1,3,3-tetramethylbutyl)phenol];Bis[2-hydroxy-5-tert-octyl-3-(benzotriazol-2-yl)phenyl]methane;Tinosorb M;Methylenebis(2-hydroxy-3-(benzotriazol-2-yl)-5-tert-octylphenyl);Bisoctyltriazole;Bisoctrizole;MBBT;FAT 75′634;2,2′-Methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazol-2-ylphenol];Eversorb 78;Mixxim ADK LA 31;JF 832;UV 360;2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-tert-octylphenol];Chiguard 5431;ADK Stab LA 31RG;LA 31RG;ADK Stab LA 31R;ADK-ARKLS LA 31;ZINC 11677911;2,2′-Methylenebis(4-tert-octyl-6-benzotriazol-2-ylphenol);Kemisorb 279;2,2′-Methylenebis[6-(2H-benzotriazole-2-yl)-4-tert-octylphenol];Bis[2-hydroxy-5-tert-octyl-3-(benzotriazole-2-yl)phenyl]methane;Tinuvin 360ED;Tinuvin 5431;UV 5431;UC 3125;Adeka Nol UC 3125;Chisorb 5431;2,2′-Methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol);T 360;126269-45-2;165670-11-1;184484-30-8;192209-76-0;215809-89-5;737758-68-8;1202656-45-8;2192337-11-2
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CAS No:
Description
Bisoctrizole is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays; also reflects and scatters UV.
DryPowder; OtherSolid; PelletsLargeCrystals
Bisoctrizole is a diarylmethane.|Bisoctrizole, or methylene bis-benzotriazolyl tetramethylbutylphenol, is a broad-spectrum organic UV filter that is marketed as Tinosorb M. It is a benzotriazole-based organic compound that absorbs, reflects, and scatters both UV-A and UV-B rays. Bisoctrizole is not approved by the FDA, but is approved in the EU and other parts of the world as a UV-filter in sunscreens, day care products and skin lightening products at a maximum concentration of 10%.
2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] Basic Attributes
658.87
658.87
403-800-1
8NT850T0YS
759873
DTXSID2046703
Characteristics
101.88000
9.58400
1.2±0.1 g/cm3
200 °C
771.6°C at 760 mmHg
>200°C
1.616
< 5 ng/L at 25 °C
1.13E-24mmHg at 25°C
Safety Information
NONH for all modes of transport
1
36/37/38-53
26-36/37/39-61
H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]|P273, and P501|H413 (100%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]|Aggregated GHS information provided by 157 companies from 1 notifications to the ECHA C&L Inventory.|Aggregated GHS information provided by 232 companies from 2 notifications to the ECHA C&L Inventory.
Toxicity
Both oral LD50 in dermal LD50 in rat is > 2000 mg/kg [MSDS]. In a developmental toxicity study of rats, the maternal and developmental no-observed-effect-level (NOEL) of bisoctrizole was the high dose level of 1000 mg/kg bw/day. Animal studies suggest that bisoctrizole mediates no phytotoxic effects.
No pharmacokinetic data available.
Drug Information
Indicated for use as a sunscreen agent in cosmetic products.|Treatment of solar urticaria
Under the conditions of _in vitro_ androgen competitive binding assay, bisoctrizole displayed no intrinsic androgenic, estrogenic, nor uterotrophic activity.
A rat and human dermal penetration study _in vitro_ indicates that bisoctrizole displays minimal absorption through the skin, with only about 0.01% and 0.06 % of the applied dose penetration through the human and rat skin membrane, respectively. Despite low dermal uptake, potential bioaccumulation after repeated skin applications cannot be excluded.|No pharmacokinetic data available.
No pharmacokinetic data available.
No pharmacokinetic data available.
Bisoctrizole is an organic UV-A filter that absorbs both UV-A and UV-B rays.
methylene bis-benzotriazolyl tetramethylphenol
2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] Use and Manufacturing
UV-360 is a high-efficiency ultraviolet absorber that can absorb 300-400nm ultraviolet rays and is widely compatible with a variety of resins. It has very low volatility and can be used with other light stabilizers or antioxidants. It is suitable for acrylic, polyester, polycarbonate, polyoxymethylene, polyamide, polyolefin, styrene polymers, elastomers, Adhesives, etc. can be molded in powder, solution or melt extrusion to prevent crystal exudation and sublimation, and can also be used for casting, thin-layer construction of fibers, paper, and wallpaper. Suitable for PP, PE, polystyrene, ABS resin, PVC, nylon, polyurethane, etc.
Adhesives and sealant chemicals
Building/construction materials not covered elsewhere
100,000 - 500,000 lb
Adhesive manufacturing|Phenol, 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
Human Drugs -> EU pediatric investigation plans
Computed Properties
Molecular Weight:658.9
XLogP3:12.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:658.39952486
Monoisotopic Mass:658.39952486
Topological Polar Surface Area:102
Heavy Atom Count:49
Complexity:989
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol]
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