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Trimethylsilylacetamide

Trimethylsilylacetamide structure

CAS No:
13435-12-6
Formula:
C5H13NOSi
Chemical Name:
Trimethylsilylacetamide
Synonyms:
Acetamide,N-(trimethylsilyl)-;N-(Trimethylsilyl)acetamide;(Acetylamino)trimethylsilane;NSC 139859;Trimethylsilylacetamide
Categories:
Chemical Reagents > Organic Reagents

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Description

WHITE TO YELLOWISH CRYSTALLINE MASS

Trimethylsilylacetamide Basic Attributes

Molecular Weight：

131.25

Exact Mass：

131.25

BRN：

741928

EC Number：

236-565-7

NSC Number：

139859

DSSTox ID：

DTXSID8065454

HScode：

29319090

Characteristics

PSA：

29.1

XLogP3：

0.60

Appearance：

White to yellow Crystalline Mass

Density：

0.859±0.06 g/cm3(Predicted)

Melting Point：

46-49 °C

Boiling Point：

104 °C @ Press: 35 Torr

Flash Point：

135 °F

Refractive Index：

1.406

Water Solubility：

reacts

Storage Conditions：

Flammables area

Safety Information

Packing level：

III

Hazard category：

4.1

Transport codes：

1325

wgk germany：

hazard class code：

36/37/38-11

safety instructions：

37/39-26

RTECS Number：

AD0250000

Marks：

Xi-F,Xi,F

Precautionary statement(s)：

P210, P240, P241, P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P405, P501

Hazard Statements：

H228

GHS Classification：

|Warning|H228 (33.33%): Flammable solid [Danger Flammable solids]|P210, P240, P241, P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Trimethylsilylacetamide Use and Manufacturing

Uses

N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).

Manufacturing Info：

Acetamide, N-(trimethylsilyl)-: ACTIVE

Computed Properties

Molecular Weight:131.25
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:131.076640573
Monoisotopic Mass:131.076640573
Topological Polar Surface Area:29.1
Heavy Atom Count:8
Complexity:95.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Downstream Products

Cefdinir

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