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Feprazone

Feprazone structure

CAS No:
30748-29-9
Formula:
C20H20N2O2
Chemical Name:
Feprazone
Synonyms:
3,5-Pyrazolidinedione,4-(3-methyl-2-buten-1-yl)-1,2-diphenyl-;3,5-Pyrazolidinedione,4-(3-methyl-2-butenyl)-1,2-diphenyl-;4-(3-Methyl-2-buten-1-yl)-1,2-diphenyl-3,5-pyrazolidinedione;Zepelin;DA 2370;Fenilprenazone;Prenazone;4-Prenyl-1,2-diphenyl-3,5-pyrazolidinedione;4-(3-Methyl-2-butenyl)-1,2-diphenyl-3,5-pyrazolidinedione;4-Prenyl-1,2-diphenyl-3,5-dioxopyrazolidine;4-(2-Isopentenyl)-1,2-diphenyl-3,5-pyrazolidinedione;Feprazone;Pheprazone;Metrazone;Analud;Methrazone;Phenylprenazone
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Feprazone is an organic molecular entity.|A pyrazole that has analgesic, anti-inflammatory, and antipyretic properties. It has been used in mild to moderate pain, fever, and inflammation associated with musculoskeletal and joint disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p15)

Feprazone Basic Attributes

Molecular Weight：

320.39

Exact Mass：

320.39

EC Number：

250-324-3

UNII：

7BVX6J0CGR

DSSTox ID：

DTXSID3023051

ATC Code：

M - Musculo-skeletal system

HScode：

2933990090

Characteristics

PSA：

40.6

XLogP3：

3.41

Density：

1.2±0.1 g/cm3

Melting Point：

156.5 °C

Boiling Point：

437.2±28.0 °C at 760 mmHg

Flash Point：

178.7±16.4 °C

Refractive Index：

1.600

Toxicity：

LD50 in male mice, rats (mg/kg): 408.8, 386.4 i.p.; 1067, >2000 orally (Bianchi, Bonardi)

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

Brotazona

Feprazone Use and Manufacturing

Feprazone is a anti-inflammatory agent used in the management of inflammatory or degenerative joint diseases.

Computed Properties

Molecular Weight:320.4
XLogP3:3.1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:320.152477885
Monoisotopic Mass:320.152477885
Topological Polar Surface Area:40.6
Heavy Atom Count:24
Complexity:462
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Ingredients	Non-Prazone.
Indication	This product can enhance the effects of coumarin oral anticoagulants, insulin, sulfonylurea oral hypoglycemic drugs, methotrexate and phenytoin sodium. It should be used with caution in reduced dosage.
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Registered Holders

Jinan JINDA Pharmaceutical Chemistry Co., Ltd.

China
Active
Tianjin Pacific CHEMICAL&PHARMACEUTICAL Co., Ltd.

China
Active

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CAS No.: 30748-29-9

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Feprazone CAS30748-29-9

CAS No.: 30748-29-9

Grade: Pharmaceutical grade

Content: 99%

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