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Tiaramide

Tiaramide structure

CAS No:
32527-55-2
Formula:
C15H18ClN3O3S
Chemical Name:
Tiaramide
Synonyms:
2(3H)-Benzothiazolone,5-chloro-3-[2-[4-(2-hydroxyethyl)-1-piperazinyl]-2-oxoethyl]-;1-Piperazineethanol,4-[(5-chloro-2-oxo-3(2H)-benzothiazolyl)acetyl]-;1-Piperazineethanol,4-[(5-chloro-2-oxo-3-benzothiazolinyl)acetyl]-;5-Chloro-3-[2-[4-(2-hydroxyethyl)-1-piperazinyl]-2-oxoethyl]-2(3H)-benzothiazolone;3-[4-(2-Hydroxyethyl)-1-piperazinylcarbonylmethyl]-5-chloro-2(3H)-benzothiazolinone;3-[4-(2-Hydroxyethyl)-1-piperazinyl]carbonylmethyl-5-chloro-2-benzothiazolinone;Tiaramide;RHC 2592A;Tialamide
Categories:
Active Pharmaceutical Ingredients > Antiallergic Drugs

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Description

Tiaramide is a member of benzothiazoles.

Tiaramide Basic Attributes

Molecular Weight：

355.84

Exact Mass：

355.84

EC Number：

251-083-7

UNII：

BB17WGM686

DSSTox ID：

DTXSID0023666

Characteristics

PSA：

89.4

XLogP3：

0.72870

Density：

1.432g/cm3

Melting Point：

159-161 °C

Boiling Point：

605.8ºC at 760mmHg

Flash Point：

320.2ºC

Refractive Index：

1.64

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

MeSH Entry Terms：

FK 1160

Computed Properties

Molecular Weight:355.8
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:355.0757403
Monoisotopic Mass:355.0757403
Topological Polar Surface Area:89.4
Heavy Atom Count:23
Complexity:459
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes