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Ampiroxicam

Ampiroxicam structure

CAS No:
99464-64-9
Formula:
C20H21N3O7S
Chemical Name:
Ampiroxicam
Synonyms:
Carbonic acid,ethyl 1-[[2-methyl-1,1-dioxido-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester;Carbonic acid,ethyl 1-[[2-methyl-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester,S,S-dioxide;2H-1,2-Benzothiazine,carbonic acid deriv.;Ampiroxicam;CP 65703;Nasil;Flucam
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Ampiroxicam(CP65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.Target: COXAmpiroxicam is a non-steroidal anti-inflammatory drug. It is a prodrug of piroxicam. Ampiroxicam inhibits the stretching response in mice induced by phenylbenzoquinone (PBQ) with maximum protective effect (MPE) of 2 mg/kg. Ampiroxicam inhibits swelling in a dose-responsive manner in the rat foot edema (RFE) assay with ED50 of 28 mg/kg at single oral dose and 7.8 mg/kg at 5 daily oral

Ampiroxicam is a benzothiazine that is the 1-[(ethoxycarbonyl)oxy]ethyl ether of piroxicam. A prodrug for piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis. It has a role as a prodrug, an analgesic, a non-steroidal anti-inflammatory drug, an antirheumatic drug and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It is a benzothiazine, a sulfonamide, an aminopyridine, a monocarboxylic acid amide, an etabonate ester and an acetal. It derives from a piroxicam.

Ampiroxicam Basic Attributes

Molecular Weight：

447.46

Exact Mass：

447.46

EC Number：

1308068-626-2

NSC Number：

759807

DSSTox ID：

DTXSID6046474

HScode：

2942000000

Characteristics

PSA：

133

XLogP3：

Appearance：

Powder

Density：

1.4±0.1 g/cm3

Melting Point：

159-161 °C

Refractive Index：

1.630

Storage Conditions：

-20°C Freezer

Toxicity：

LD50 orally in male, female rats: 1798, 747 mg/kg (Iijima)

Safety Information

Transport codes：

NONH for all modes of transport

RTECS Number：

FG1602400

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

ampiroxicam

Ampiroxicam Use and Manufacturing

Prodrug of Piroxicam. Anti-inflammatory.

Computed Properties

Molecular Weight:447.5
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:447.11002119
Monoisotopic Mass:447.11002119
Topological Polar Surface Area:133
Heavy Atom Count:31
Complexity:808
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Ampiroxicam

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Ampiroxicam

CAS No.: 99464-64-9

Content: 99.00%

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Huangshi pharma Contact Supplier

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AMPIROXICAM 99.99%

CAS No.: 99464-64-9

Grade: Pharmaceutical Grade

Content: 99.99%

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