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Darifenacin

Darifenacin structure

CAS No:
133099-04-4
Formula:
C28H30N2O2
Chemical Name:
Darifenacin
Synonyms:
3-Pyrrolidineacetamide,1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-,(3S)-;3-Pyrrolidineacetamide,1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-,(S)-;(3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide;Darifenacin;(S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide;UK 88525;(3S)-3-(2-Amino-2-oxo-1,1-diphenylethyl)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]-1-pyrrolidine;(S)-3-(1-Carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine;(S)-(-)-3-(1-Carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine;(S)-2-[1-[2-(2,3-Dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl]-2,2-diphenylacetamide;(3S)-(1-Carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine;Vesigard;2-[(3S)-1-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

ChEBI: 2-[(3S)-1-Ethylpyrrolidin-3-yl]-2,2-diphenylacetamide in which one of the hydrogens at the 2-position of the ethyl group is substituted by a 2,3-dihydro-1-benzofuran-5-yl group. It is a selective antagonist for the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions, and is used as the hydrobromide salt in the management of urinary incontinence.Darifenacin is a novel muscarinic M3 selective antagonist for the once-daily oral treatment o

Darifenacin is an anticholinergic and antispasmotic agent used to treat urinary incontinence and overactive bladder syndrome. Darifenacin has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.

Darifenacin Basic Attributes

Molecular Weight：

426.55

Exact Mass：

426.55

EC Number：

603-704-1

DSSTox ID：

DTXSID2048290|DTXSID20678700

Characteristics

PSA：

55.56000

XLogP3：

4.50

Density：

1.192±0.06 g/cm3(Predicted)

Boiling Point：

614.3±55.0 °C(Predicted)

Flash Point：

325.3±31.5 °C

Refractive Index：

1.624

Vapor Pressure：

5E-15mmHg at 25°C

Specific rotation：

25D -20.6° (c = 1.0 in methylene chloride)

Toxicity

Hepatotoxicity：

Like most anticholinergic agents, darifenacin has not been linked to episodes of liver enzyme elevations or clinically apparent liver injury. Darifenacin is metabolized by CYP 3A4 and 2D6, so that drug-drug interactions may occur. A major reason for its safety may relate to the low daily dose.

Drug Information

LiverTox Summary：

Drug Classes：

Anticholinergic Agents

Darifenacin Use and Manufacturing

Treatment for an overactive bladder.

Computed Properties

Molecular Weight:426.5
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:426.230728204
Monoisotopic Mass:426.230728204
Topological Polar Surface Area:55.6
Heavy Atom Count:32
Complexity:607
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Darifenacin

CAS No.: 133099-04-4

Content: 99.00%

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