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Tenoxicam

Tenoxicam structure

CAS No:
59804-37-4
Formula:
C13H11N3O4S2
Chemical Name:
Tenoxicam
Synonyms:
2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide,4-hydroxy-2-methyl-N-2-pyridinyl-,1,1-dioxide;Ro 12-0068;Tenoxicam;Tilcotil;Liman;Mobiflex;Tilatil;Dolmen;Alganex;Rexalgan;Oxamen-L;Epicotil;Soral;Texamen
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties.Target: COXTenoxicam is a non-steroidal anti-inflammatory drug (NSAID). Tenoxicam-treated patients had significant decrease in nitrite levels (p = 0.036) and XO activity (p = 0.01), but their SOD, GSH-Px enzyme activities, and MDA levels were unchanged from baseline. Tenoxicam may have antioxidant effects, and it may reduce nitrite levels, indicating an alteration of NO pathways [1]. Tenoxicam was administered

Tenoxicam Basic Attributes

Molecular Weight：

337.37

Exact Mass：

337.37

EC Number：

1312995-182-4

HScode：

2934999090

Characteristics

PSA：

136

XLogP3：

1.1

Appearance：

yellow crystalline powder

Density：

1.59 g/cm³

Melting Point：

211 °C (decomp)

Refractive Index：

1.741

Water Solubility：

H2O: 61.9mg/L(32 ºC);Practically insoluble in water, sparingly soluble in methylene chloride, very slightly soluble in anhydrous ethanol. It dissolves in solutions of acids and alkalis.

Storage Conditions：

-20°C Freezer

Safety Information

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

23/24/25-36/37/38

safety instructions：

36/37/39-45-36-26-36/37

RTECS Number：

XJ9095060

Marks：

T,Xi

Precautionary statement(s)：

P261-P280-P301 + P310-P311

Hazard Statements：

H301-H311-H331

Tenoxicam Use and Manufacturing

Nonsteroidal anti-inflamatory agent.It has anti-inflammatory, analgesic and antipyretic effects, and can also inhibit platelet aggregation. It has obvious inhibitory effect on the release of lymphocytes, monocytes and basophils, and can produce double inhibition of cyclooxygenase and lipoxygenase. It has a fast onset and relieves pain in about 30 minutes. It has a long-acting effect and a half-life of 70-90 hours. It can be administered once a day. Used for rheumatoid arthritis, degenerative arthritis, ankylosing spondylitis, tendonitis, bursitis, shoulder or hip joint inflammation, strain, sprain, acute gout, etc. It is well tolerated.

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