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2-Amino-4-thiazoleacetic acid

2-Amino-4-thiazoleacetic acid structure

CAS No:
29676-71-9
Formula:
C5H6N2O2S
Chemical Name:
2-Amino-4-thiazoleacetic acid
Synonyms:
4-Thiazoleacetic acid,2-amino-;2-Amino-4-thiazoleacetic acid;2-Aminothiazole-4-acetic acid;2-Amino-4-thiazolylacetic acid;SQ 272;(2-Amino-4-thiazoyl)acetic acid;2-(2-Amino-4-thiazolyl)acetic acid;(2-Amino-1,3-thiazol-4-yl)acetic acid;2-Aminothiazol-4-acetic acid;2-(2-Amino-4-thiazole)acetic acid;2-(2-Amino-1,3-thiazol-4-yl)acetic acid;2-(2-Azaniumyl-1,3-thiazol-4-yl)acetate;63417-46-9
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

Almost white to light beige crystalline powder

2-amino-4-thiazole acetic acid is a light orange powder. (NTP, 1992)

2-Amino-4-thiazoleacetic acid Basic Attributes

Molecular Weight：

158.18

Exact Mass：

158.18

BRN：

127415

EC Number：

249-769-6

UNII：

QSH3O4TNJT

DSSTox ID：

DTXSID0024509

HScode：

2934100090

Characteristics

PSA：

104

XLogP3：

-0.33

Appearance：

almost white to light beige crystalline powder

Density：

1.6±0.1 g/cm3

Melting Point：

130 °C (dec.)(lit.)

Boiling Point：

399.0±17.0 °C at 760 mmHg

Flash Point：

195.1±20.9 °C

Refractive Index：

1.671

Water Solubility：

H2O: 6.5 g/L (20 ºC)

Storage Conditions：

Refrigerator

Vapor Pressure：

4.4E-07mmHg at 25°C

Air and Water Reactions：

Insoluble in water.

Reactive Group：

Acids, Carboxylic

Reactivity Profile：

An organosulfide and amine derivative, carboxylic acid. Look at Reactive Groups 20 (organosulfides), 7 (amines), and 3 (carboxylic acids) may give indications about reactive tendencies.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-37/39

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

Fire Hazards：

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 50 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fire Fighting：

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Nonfire Spill Response：

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. (NTP, 1992)

Personal Protective Equipment：

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Drug Information

Health Hazards：

SYMPTOMS: Exposure to this compound may cause irritation. ACUTE/CHRONIC HAZARDS: This compound may cause irritation. (NTP, 1992)

First Aid：

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

MeSH Entry Terms：

(2-amino-1,3-thiazol-4-yl)acetic acid

2-Amino-4-thiazoleacetic acid Use and Manufacturing

Methods of Manufacturing

With chloro or bromo acetyl ethyl acetate and thiourea condensation, and then hydrolysis system.

Uses

It is used in the manufacture of cephalosporins and is an intermediate of cefotiam

Computed Properties

Molecular Weight:158.18
XLogP3:0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:158.01499861
Monoisotopic Mass:158.01499861
Topological Polar Surface Area:104
Heavy Atom Count:10
Complexity:142
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 2-Amino-4-thiazoleacetic acid

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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2-Amino-4-thiazoleacetic acid

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