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4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenyl phosphate (1:4)

4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenyl phosphate (1:4) structure

CAS No:
76748-86-2
Formula:
C29H32ClN5O2.4H3O4P
Chemical Name:
4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenyl phosphate (1:4)
Synonyms:
Phenol,4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-,phosphate (1:4);Phenol,4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-,phosphate (1:4) (salt);4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenyl phosphate (1:4);Pyronaridine tetraphosphate
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Pyronaridine tetraphosphate is a Mannich base anti-malarial with demonstrated efficacy against drug resistant Plasmodium falciparum, P. vivax, P. ovale and P. malariae.

4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenyl phosphate (1:4) Basic Attributes

Molecular Weight：

910.03

Exact Mass：

909.132019

UNII：

2T289F9ACO

Characteristics

PSA：

380

XLogP3：

2.32020

Density：

1.357g/cm3

Melting Point：

233-236° (dec)

Boiling Point：

657.2ºC at 760 mmHg

Flash Point：

351.3ºC

Refractive Index：

1.72

Water Solubility：

acetic acid: soluble5mg/mL

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice (mg/kg): 251 ±33 i.m.; 1368 ±239 orally (Shao)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

63-22-41

safety instructions：

26-36/37-39

RTECS Number：

SK4920000

Marks：

Precautionary statement(s)：

P280-P301 + P312 + P330

Hazard Statements：

H302-H361

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P264, P270, P273, P280, P281, P301+P310, P305+P351+P338, P308+P313, P310, P321, P330, P405, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)

MeSH Entry Terms：

2-methoxy-7-chloro-10-(3',5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-1,5-naphthyridine

4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenyl phosphate (1:4) Use and Manufacturing

antimalarial

Computed Properties

Molecular Weight:910.0
Hydrogen Bond Donor Count:14
Hydrogen Bond Acceptor Count:23
Rotatable Bond Count:7
Exact Mass:909.1320353
Monoisotopic Mass:909.1320353
Topological Polar Surface Area:385
Heavy Atom Count:57
Complexity:757
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes

Recommended Suppliers of 4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenyl phosphate (1:4)

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Pyranoridine phosphate

CAS No.: 76748-86-2

Content: 99.00%

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Guide of 4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenyl phosphate (1:4)

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenyl phosphate (1:4)

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