6-Chloro-2-pyridinecarbonitrile
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6-Chloro-2-pyridinecarbonitrile
structure -
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CAS No:
33252-29-8
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Formula:
C6H3ClN2
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Chemical Name:
6-Chloro-2-pyridinecarbonitrile
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Synonyms:
2-Pyridinecarbonitrile,6-chloro-;Picolinonitrile,6-chloro-;6-Chloro-2-pyridinecarbonitrile;2-Chloro-6-cyanopyridine;6-Chloropyridine-2-carbonitrile;2-Chloropyridine-6-carbonitrile;6-Chloropicolinonitrile
- Categories:
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CAS No:
6-Chloro-2-pyridinecarbonitrile Basic Attributes
138.55
138.55
251-429-7
ZS4YVY14OF
DTXSID40186897
2933399090
Characteristics
36.7
1.9
Off-white Cryst
1.3±0.1 g/cm3
86-88 °C
245.3ºC at 760 mmHg
102.1±21.8 °C
1.566
Safety Information
III
6.1
UN 2811 6.1/PG 3
3
22-37/38-41-36/37/38
26-36/37/39-37
Xn,T,Xi
P261-P280-P301 + P310-P305 + P351 + P338
H301-H315-H318-H335
|Danger|H301 (91.3%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
6-Chloro-2-pyridinecarbonitrile Use and Manufacturing
(2) The following may be mentioned as preferred compounds of the general formula (I) which can be prepared by the process according to the invention: 2, 3-dichloropyridine 2, 4-dichloropyridine 2, 6-dichloropyridine 2-chloro-3-cyano-pyridine 2-chloro-6-cyano-pyridine methyl 6-chloro-pyridine-2-carboxylate ethyl 6-chloro-pyridine-2-carboxylate N, N-dimethyl-6-chloro-pyridine-2-carboxamide N, N-diethyl-6-chloro-pyridine-2-carboxamide ...The following may be mentioned as compounds of the general formula (I) which can preferably be prepared using the process according to the invention: 2, 3-Dichloropyridine 2, 4-Dichloropyridine 2, 6-Dichloropyridine 2-Chloro-3-cyano-pyridine 2-Chloro-6-cyano-pyridine Methyl 6-chloro-pyridine-2-carboxylate Ethyl 6-chloro-pyridine-2-carboxylate N, N-Dimethyl-6-chloro-pyridine-2-carboxamide N, N-Diethyl-6-chloro-pyridine-2-carboxamide ...Under an argon stream, N- (4-phenylbenzoyl) benzamidine (300 mg, 1.0 mmol), The title compound of this step is prepared by the method described in the first step of Example 1, That is, 2-(4-Boc-piperazin-1-yl)pyrimidine-5-boronic acid pinacol ester (2.70 g, 6.93 mmol), The title compound of this step was prepared by the method described in Example 1, Step 1, namely, 2-[4-(Boc)piperazin-1-yl]pyrimidine-5-boronic acid pinacol ester (2.70 g, 6.93 mmol),
It can be used as substrate for Negishi coupling reaction with aryl zinc halide catalyzed by Pd-NHC (PEPPSI-Ipr, catalog number 668032).
Computed Properties
Molecular Weight:138.55
XLogP3:1.9
Hydrogen Bond Acceptor Count:2
Exact Mass:137.9984758
Monoisotopic Mass:137.9984758
Topological Polar Surface Area:36.7
Heavy Atom Count:9
Complexity:137
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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