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2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole structure

CAS No:
303727-31-3
Formula:
C20H14ClN3O
Chemical Name:
2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole
Synonyms:
2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole;L-779450;2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol;4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(pyridin-4-yl)-1H-iMidazole;4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(4-pyridyl)-1H-iMidazole;Phenol, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-iMidazol-5-yl]-;2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-iMidazol-4-yl)phenol;2-chloro-5-(2-phenyl-4-(pyridin-4-yl)-1H-imidazol-5-yl)phenol
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

L-779450 is a potent and selective B-Raf kinase inhibitor with a Kd of 2.4 nM.

2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol is a member of imidazoles.

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole Basic Attributes

Molecular Weight：

347.804

Exact Mass：

347.08300

DSSTox ID：

DTXSID40433252

HScode：

2933990090

Characteristics

PSA：

61.8

XLogP3：

5.16470

Density：

1.335g/cm3

Boiling Point：

579.783ºC at 760 mmHg

Flash Point：

304.442ºC

Refractive Index：

1.671

Storage Conditions：

Store at +4°C

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

Precautionary statement(s)：

P280-P301 + P310 + P330-P304 + P340 + P312-P305 + P351 + P338-P337 + P313

Hazard Statements：

H301-H315-H319-H335

Drug Information

MeSH Entry Terms：

L-779,450

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole Use and Manufacturing

Raf kinase inhibitor, a potential treatment for neurotraumatic diseases.Its effects also suppress DNA synthesis and induce apoptosis in targeted cells, presenting new applications in treating certain types of cancers.

Computed Properties

Molecular Weight:347.8
XLogP3:4.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:347.0825398
Monoisotopic Mass:347.0825398
Topological Polar Surface Area:61.8
Heavy Atom Count:25
Complexity:425
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Latest News
Learn More Other Chemicals

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

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