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Alisol B

Alisol B structure

CAS No:
18649-93-9
Formula:
C30H48O4
Chemical Name:
Alisol B
Synonyms:
Dammar-13(17)-en-3-one,24,25-epoxy-11,23-dihydroxy-,(8α,9β,11β,14β,23S,24R)-;8α,9β,14β-Dammar-13(17)-en-3-one,24,25-epoxy-11β,23-dihydroxy-,(23S,24R)-;(8α,9β,11β,14β,23S,24R)-24,25-Epoxy-11,23-dihydroxydammar-13(17)-en-3-one;Alisol B;16-Deoxoalisol C;20054-95-9
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Alisol B is a potentially novel therapeutic compound for bone disorders by targeting the differentiation of osteoclasts as well as their functions.IC50 Value:Target:In vitro: The in vitro cultured human renal tubular epithelial HK-2 cells were intervened with 5 ng/mL transforming growth factor-beta (TGF-beta), 0.1 micromol C3a, and 0.1 micromol C3a + 10 micromol alisol B, respectively. Exogenous C3a could induce renal tubular EMT. Alisol B was capable of suppressing C3a induced EMT [1].

Alisol B Basic Attributes

Molecular Weight：

444.65

Exact Mass：

472.70

HScode：

29329990

Characteristics

PSA：

70.1

XLogP3：

5.20400

Density：

1.12±0.1 g/cm3(Predicted)

Melting Point：

166-168 °C

Boiling Point：

575.1±50.0 °C(Predicted)

Flash Point：

181.2±23.6 °C

Refractive Index：

1.560

Vapor Pressure：

1.27E-15mmHg at 25°C

Drug Information

MeSH Entry Terms：

alisol B

Computed Properties

Molecular Weight:472.7
XLogP3:4.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:472.35526001
Monoisotopic Mass:472.35526001
Topological Polar Surface Area:70.1
Heavy Atom Count:34
Complexity:917
Defined Atom Stereocenter Count:6
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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