Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)-

To the reaction flask was added 2.5M BuLi in tetrahydrofuran(1.2 mol, 480 ml), Liquid nitrogen cooled to -78 , Was added dropwise acetonitrile (100ml) to the system, -78 ° C for 10 min, spare.Tetrahydrofuran was then added dropwise to the reaction solution Compound VII (0.6 mol) of (100ml), About 1.5h dropwise added.Keep at -78 ° C, The reaction was stirred for 2h, TLC point plate, Raw material fully reacted.The reaction solution was slowly warmed to -10 ° C, Acetic acid was added dropwise, Stir overnightA solid precipitation, Suction filtration, The filter cake was washed successively with tetrahydrofuran (300 ml)Water (300 ml), Ether (300 ml) and ethyl acetate (300 ml)dry, Compound VIII (0.58 mol) was obtained in 96percent yield.EXAMPLE 5 Example 28Example 20

Molecular Weight:271.27
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:271.09569129
Monoisotopic Mass:271.09569129
Topological Polar Surface Area:91.2
Heavy Atom Count:20
Complexity:491
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes