α-Amanitin
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α-Amanitin
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CAS No:
11030-71-0
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Formula:
C39H54N10O14S
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Chemical Name:
α-Amanitin
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Synonyms:
α-Amanitin
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CAS No:
Description
Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These peptides are important in the study of transcription. Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.
Drug Information
Substances which, when ingested, inhaled, or absorbed, or when applied to, injected into, or developed within the body in relatively small amounts may, by their chemical action, cause damage to structure or disturbance of function. (From Dorland, 27th ed) (See all compounds classified as Poisons.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Compounds that inhibit cell production of DNA or RNA. (See all compounds classified as Nucleic Acid Synthesis Inhibitors.)
Amanitin
Computed Properties
Molecular Weight:904.0
XLogP3:-2.3
Hydrogen Bond Donor Count:13
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:7
Exact Mass:903.34326857
Monoisotopic Mass:903.34326857
Topological Polar Surface Area:383
Heavy Atom Count:63
Complexity:1760
Undefined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes