Apricoxib
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Apricoxib
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CAS No:
197904-84-0
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Formula:
C19H20N2O3S
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Chemical Name:
Apricoxib
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Synonyms:
Benzenesulfonamide,4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-;4-[2-(4-Ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]benzenesulfonamide;4-Methyl-2-(4-ethoxyphenyl)-1-(4-sulfamoylphenyl)pyrrole;CS 706;Apricoxib;TG 01;R 109339
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CAS No:
Description
Apricoxib has been used in trials studying the treatment and prevention of Lung Cancer, Breast Cancer, Pancreatic Cancer, Non Small Cell Lung Cancer, and Metastatic Pancreatic Cancer, among others.|Apricoxib is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related metabolic pathways may represent crucial regulators of cellular proliferation and angiogenesis.
Apricoxib Use and Manufacturing
Apricoxib, is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also hasanticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy.
Computed Properties
Molecular Weight:356.4
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:356.11946368
Monoisotopic Mass:356.11946368
Topological Polar Surface Area:82.7
Heavy Atom Count:25
Complexity:517
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes