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Latanoprost Lactone Diol

Latanoprost Lactone Diol structure

CAS No:
145667-75-0
Formula:
C18H24O4
Chemical Name:
Latanoprost Lactone Diol
Synonyms:
LATANOPROST LACTONE DIOL;(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(3R)-3-HYDROXY-5-PHENYLPENTYL]-2H-CYCLOPENTA[B]FURAN-2-ONE;(3AR,4R,5R,6AS)-5-HYDROXY-4-((3R)-3-HYDROXY-5-PHENYLPENTYL)HEXAHYDROCYCLOPENTA[B]FURAN-2-ONE;LP-diol (LT-DI)(Latanprost);LP-diol;2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]-, (3aR,4R,5R,6aS)-;(3AR,4R,5R,6aS)-5-Hydroxy-4-((R)-3-hydroxy-5-phenyl-pentyl)hexahydro-2H-cyclopenta[b]furan-2-one;(3AR,4R,5R,6aS)-5-Hydroxy-4-((R)-3-hydroxy-5-phenyl-pentyl)hexahydro-2H-cyclopenta[b]furan-2-o
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP)[1].

Latanoprost Lactone Diol Basic Attributes

Molecular Weight：

304.38

Exact Mass：

304.167450

DSSTox ID：

DTXSID30437648

Characteristics

PSA：

66.8

XLogP3：

0.60

Appearance：

White or almost white crystalline powder

Density：

1.202

Melting Point：

69-71 ºC

Boiling Point：

523.0±35.0 °C(Predicted)

Flash Point：

190.3±19.4 °C

Refractive Index：

1.568

Vapor Pressure：

0mmHg at 25°C

Safety Information

Precautionary statement(s)：

P201, P202, P264, P280, P281, P302+P352, P308+P313, P321, P332+P313, P362, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (66.67%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P264, P280, P281, P302+P352, P308+P313, P321, P332+P313, P362, P405, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Latanoprost Lactone Diol Use and Manufacturing

(3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]2H-cyclopenta[b]furan-2-one is phenyl-substituted prostaglandin and a potent and selective antiglaucoma agents.

Computed Properties

Molecular Weight:304.4
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:304.16745924
Monoisotopic Mass:304.16745924
Topological Polar Surface Area:66.8
Heavy Atom Count:22
Complexity:377
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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