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Amenamevir

Amenamevir structure

CAS No:
841301-32-4
Formula:
C24H26N4O5S
Chemical Name:
Amenamevir
Synonyms:
2H-Thiopyran-4-carboxamide,N-(2,6-dimethylphenyl)tetrahydro-N-[2-[[4-(1,2,4-oxadiazol-3-yl)phenyl]amino]-2-oxoethyl]-,1,1-dioxide;Amenamevir;ASP 2151
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Amenamevir has been used in trials studying the treatment of Herpes Zoster, Herpes Simplex, Herpes Genitalis, and Safety of Amenamevir.|Amenamevir is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2. Amenamenir stabilizes the interaction between the helicase-primase and its DNA substrates, preventing the progression through helicase or primase catalytic cycles, thus interfering with viral DNA replication and viral growth.

Amenamevir Basic Attributes

Molecular Weight：

482.555

Exact Mass：

482.55

UNII：

94X46KW4AE

NCI Thesaurus Code：

C90782

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

131

XLogP3：

2.6

Density：

1.360±0.06 g/cm3(Predicted)

Drug Information

MeSH Entry Terms：

amenamevir

Computed Properties

Molecular Weight:482.6
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:482.16239112
Monoisotopic Mass:482.16239112
Topological Polar Surface Area:131
Heavy Atom Count:34
Complexity:800
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes