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Selank peptide

Selank peptide structure

CAS No:
129954-34-3
Formula:
C33H57N11O9
Chemical Name:
Selank peptide
Synonyms:
Selank peptide;SelankAcetate;PL14736;L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline;L-THREONYL-L-LYSYL-L-PROLYL-L-ARGINYL-L-PROLYLGLYCYL-L-PROLINE; MONOACETATE;H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH;SLANK;Selank peptid
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine in mice. It also decreases expression of the inflammation-related genesIl2rgandXcr1in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.

SELANK Synthetic is a single, non-glycosylated polypeptide chain containing 7 amino acids, having a molecular mass of 751.89 Dalton and a Molecular formula of C33H57N11O9.

Selank peptide Basic Attributes

Molecular Weight：

751.87

Exact Mass：

751.43407244

EC Number：

232-660-2

UNII：

TS9JR8EP1G

Characteristics

Density：

1.53±0.1 g/cm3(Predicted)

Melting Point：

134-136 °C

PKA：

3.43±0.20(Predicted)

Drug Information

MeSH Entry Terms：

Selank

Selank peptide Use and Manufacturing

Selank peptide has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and antistress drug that relieves aggression and fear reaction in different animal species. It is often prescribed for its anxiolytic properties, immune improvement, gastric protection, and with opioid and alcohol withdrawal/ dependence. It also has a nootropic action, which positively influences the formation of memory and learning processes, and marked immunomodulatory activity.

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