3-BroMo-1H-pyrazolo[3,4-b]pyridin-5-aMine

K2CO3 (0.233 g, 1.68 mmol) was added to a solution of 3-bromo-l- tosyl-lH-pyrazolo[3, 4-b]pyridin-5-amine (0.206 g, 0.56 mmol) in MeOH/H2O (3:1, 8 mL), and the reaction mixture was stirred at room temperature overnight. The reaction mixture was concentrated. The resulting residue was taken up in water (10 mL), and the pH was adjusted to about 7 with acetic acid. The aqueous layer was extracted with ethyl acetate (3 X 50 mL). The combined organic layers were dried, filtered and concentrated. The crude product was purified by column chromatography, eluting with hexanes/ethyl acetate (1:4) to give 3-bromo-lH-pyrazolo[3, 4-b]pyridin-5-amine (0.036 g, 30%) as a solid.

Molecular Weight:213.03
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Exact Mass:211.96976
Monoisotopic Mass:211.96976
Topological Polar Surface Area:67.6
Heavy Atom Count:11
Complexity:154
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes