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BCTC

BCTC structure

CAS No:
393514-24-4
Formula:
C20H25ClN4O
Chemical Name:
BCTC
Synonyms:
BCTC;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-diMethylethyl)phenyl]-1-piperazinecarboxaMide (BCTC);N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide

Description

BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.Target: TRPM8in vitro: BCTC is a potent and specific antagonist of TRPM8, exerts an anti-tumor effect on the androgen-independent PCa DU145 cells, and the mechanism of how the inhibition functions. BCTC exerts an anti-proliferative effect on DU145 cells and induces tumor suppression through G0/G1 cell cycle arrest, and inhibition of migr

BCTC Basic Attributes

Molecular Weight：

372.8917

Exact Mass：

372.171692

Characteristics

PSA：

48.5

XLogP3：

4.3

Appearance：

white to beige

Density：

1.2±0.1 g/cm3

Melting Point：

150-152℃

Flash Point：

293.4±30.1 °C

Refractive Index：

1.610

Water Solubility：

DMSO: >10mg/mL

Storage Conditions：

Store at RT

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Marks：

Hazard Statements：

H302

BCTC Use and Manufacturing

BCTC is a antagonists of TRPA1 and TRPV1, a non-selective cation channel gated by noxious heat, vanilloids and extracellular protons. BCTC inhibits both capsaicin and proton activation.

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Guide of BCTC

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing

BCTC

SDS

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