3,4'-BIPYRIDIN-2'-AMINE
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3,4'-BIPYRIDIN-2'-AMINE
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CAS No:
865604-20-2
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Formula:
C10H9N3
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Chemical Name:
3,4'-BIPYRIDIN-2'-AMINE
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CAS No:
Safety Information
41
26-39
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
3,4'-BIPYRIDIN-2'-AMINE Use and Manufacturing
2N Na2C03 (20 mL, 0.04 mol) was added to a suspension of aminopyridine (1) (l. OOg, 5. 78 mmol) and boronic acid (2) (1.06 g, 8. 67 mmol) in toluene (60 mL) and the mixture was purged with nitrogen gas. Bis (diphenylphosphino) ferrocenepalladium (II) chloride, dichloromethane complex [hereinafter'PdCl2 (dppf)'] (0.17 g, 0.21 mmol) was added and the mixture was refluxed under nitrogen for 1.5 hours. Ethyl acetate was added and the solution was washed with water, dried over Na2S04 and adsorbed onto silica by removal of solvent in vacuo. The residue was chromatographed on silica, eluting with MeOH/EtOAc (1: 15) to give product (3) as a powder (0. 87 g, 87percent). APCI-MS found: [M+H] +=172.
Computed Properties
Molecular Weight:171.20
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:171.079647300
Monoisotopic Mass:171.079647300
Topological Polar Surface Area:51.8
Heavy Atom Count:13
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes