6-Bromooxazolo[4,5-b]pyridine
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![6-Bromooxazolo[4,5-b]pyridine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/9c7b7d027a7e4402b90e8661be0e32c2.png "6-Bromooxazolo[4,5-b]pyridine")
6-Bromooxazolo[4,5-b]pyridine
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CAS No:
1260863-86-2
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Formula:
C6H3BrN2O
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Chemical Name:
6-Bromooxazolo[4,5-b]pyridine
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Synonyms:
6-Bromooxazolo[4,5-b]pyridine;6-bromo-[1,3]oxazolo[4,5-b]pyridine;oxazolo[4,5-b]pyridine, 6-bromo-;6-Bromo[1,3]oxazolo[4,5-b]pyridine;6-bromo-oxazolo[4,5-b]pyridine;PubChem22321;SCHEMBL621671;CTK4B4947;KS-00000OCD;DTXSID40620887
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CAS No:
Safety Information
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
6-Bromooxazolo[4,5-b]pyridine Use and Manufacturing
Preparation 56-Bromo-oxazolo[4, 5-b]pyridine[00122] 2-Amino-5-bromo-3-hydroxypyridine (200 mg, 1.06 mmol) is dissolved in 3 ml of triethylortoformate and a catalytic amount of p-toluenesulfonic acid is added. The mixture is heated to reflux for 5 h, then cooled, diluted with DCM and washed with saturated sodium bicarbonate solution. The organic phase is dried over anhydrous sodium sulfate and evaporated to dryness. The residue is purified by flash column chromatography to afford 212 mg (60percent) of the title compound.
Computed Properties
Molecular Weight:199.00
XLogP3:1.7
Hydrogen Bond Acceptor Count:3
Exact Mass:197.94288
Monoisotopic Mass:197.94288
Topological Polar Surface Area:38.9
Heavy Atom Count:10
Complexity:133
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
