2-Bromothieno[3,2-c]pyridin-4(5H)-one

INTERMEDIATE 49 2-Bromothieno [3, [2-C]] pyridin-4 (5H)-one A solution of [(2E)-3- (5-BROMOTHIEN-2-YL)] acryloyl azide (18.00 g, 69.7 mmol) solved in dichloromethane (100 mL) was added dropwise to diphenyl ether (90 mL) at [150] [°C.] The temperature was increased to [220°C] for lh. The mixture was cooled to room temperature followed by the addition of ether. The solid precipitated and was separated by filtration. Yield: 13.58 g (84.6 [percent).APOS;H] NMR (270 MHz, DMSO-d6) 8 ppm 6.82 [(D, ] [J=7.] 13 Hz, 1 H) 7.27 (d, [J=6.] 86 Hz, 1 H) 7.54 (s, 1 H) 11. 55 (s, 1 H); MS [230.] 1 [(M-H)] [+] ; Purity (HPLC) [92percent.]General procedure: Diphenyl ether (3 mL) was added into a 10 mL round bottom flask with an air condensation tube, the flask was heated to 240C, to above solution was slowly injected a solution of compound 3.7 (188 mg, 0.74 mmol) in dichloromethane (3 mL) by a syringe, the reaction system was stirred at 240C for 20min and then cooled down to 50C, the reaction system was poured into petroleum ether (50 mL) and stirred for 2h, the resulting mixture was filtered, the filter cake was rinsed with petroleum ether, dried over to afford compound 3.8 (90 mg, yield: 54%) as a dark grey solid. m/z: [M+H]+227

Molecular Weight:230.08
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:228.91970
Monoisotopic Mass:228.91970
Topological Polar Surface Area:57.3
Heavy Atom Count:11
Complexity:219
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes