3-BROMO-7-HYDROXY-4-METHYLCHROMEN-2-ONE

N-bromosuccinimide (0.98 g, 5.5 mmol) was added slowly to a suspension of 7-hydroxy-4-methyl-2H-chromen-2-one [15] (0.88 g, 5.0 mmol) in PEG-400 (10 g). After stirring at room temperature for 3 h, the reaction mixture was diluted with brine (100 mL) and extracted with CHGeneral procedure: The appropriate 7-hydroxycoumarin 1a-g (2.0 mmol for 2a-gand 2i-r; 3.0 mmol for 1h) was suspended in anhydrous acetone(10 mL) before adding potassium carbonate (for 2a-g and 2i-r: 0.83 g, 6.0 mmol; for 1h: 1.2 g, 9.0 mmol), the suitable monohalide(for 1h: 2-[4-(bromomethyl)phenyl]ethanol, 3.0 mmol) or dihalide(for 2a-g and 2i-r: 6.0 mmol of alpha, alpha'-dibromo(chloro)-xylenes or trans-1, 4-dibromo-2-butene; 10 mmol of 1, omega-dibromoalkanes) anda catalytic amount of KI in a Pyrex vessel charged with a magnetic stirring bar and aWeflon bar. The vessel was placed in a microwave apparatus and irradiated at 130 C for 30 min. After cooling to room temperature, the inorganic residue was filtered off after thorough washing with CH2Cl2. The solutionwas concentrated to dryness andthe resulting crude was purified as detailed below.

Molecular Weight:255.06
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:253.95786
Monoisotopic Mass:253.95786
Topological Polar Surface Area:46.5
Heavy Atom Count:14
Complexity:298
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes