CHEMBRDG-BB 6631006

Hydroxyquinolone (II) was obtained using the experimental method described in Ref. [14], by heating the N, N′-di-(2-methylphenyl)malonamide (I) (0.56 g, 2.0 mmol) in 3.5 mL methanesulfunic acid, which contains 10percent phosphorus pentoxide at 150 °C, for 90 min. The dark viscous solution was allowed to cool. Water was added, and the resultant gum solidified on prolonged standing. The solid was filtered and then dissolved in 100 mL 10percent sodium hydroxide. The aqueous solution was filtered to remove insoluble material and slowly acidified to pH  4 with 10percent hydrochloric acid. The resulting crude precipitates were collected, washed with water and dried to afford 8-methyl-4-hydroxyquinoline-2-(1H)-one (II) as creamy crystals (0.30 g, 87percent), mp: 357–358 °C (reported 360 °C [13]); FT-IR (KBr, cm

Molecular Weight:175.18
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:175.063328530
Monoisotopic Mass:175.063328530
Topological Polar Surface Area:49.3
Heavy Atom Count:13
Complexity:260
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes