CINNAMYCIN
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CINNAMYCIN
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CAS No:
110655-58-8
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Formula:
C89H125N25O25S3
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Chemical Name:
CINNAMYCIN
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Synonyms:
antibioticnsc-71936;lanthiopeptin;nsc-71936;Lanthiopeptin, Ro 09-0198
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CAS No:
Characteristics
872
-10.74
brown solid
1.59±0.1 g/cm3(Predicted)
1.724
acetonitrile: water: 5 mg/mL
2-8°C
CINNAMYCIN Use and Manufacturing
Cinnamycin (lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of Streptoverticillium. Cinnamycin is a potent indirect inhibitor of phospholipase A2, acting by specifically sequestering phosphatidylethanolamine (PE), a major component of the mammalian plasma cell membrane. Cinnamycin induces trans-bilayer phospholipid movement in cell membranes to expose internally bound PE. At high surface concentrations of PE, cinnamycin induces membrane re-organisation including membrane fusion and alteration of gross morphology.
Computed Properties
Molecular Weight:2041.3
XLogP3:-9.4
Hydrogen Bond Donor Count:27
Hydrogen Bond Acceptor Count:31
Rotatable Bond Count:20
Exact Mass:2039.8440581
Monoisotopic Mass:2039.8440581
Topological Polar Surface Area:872
Heavy Atom Count:142
Complexity:4510
Undefined Atom Stereocenter Count:20
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes