 Home > Encyclopedia > Combretastatin A4

Combretastatin A4

Combretastatin A4 structure

CAS No:
117048-59-6
Formula:
C18H20O5
Chemical Name:
Combretastatin A4
Synonyms:
Phenol,2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-;Phenol,2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]-,(Z)-;2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;Combretastatin A4;NSC 817373;CRC 87-09;NSC 613729;Combretastatin 4;CA 4;2′-Deoxycombretastatin A1;2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;cis-Combretastatin A4;Cis-Combretastatin A4;C 7744;848866-48-8;1052086-67-5
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Request for Quotation

Description

Crystalline Powder

Combretastatin A4 Basic Attributes

Molecular Weight：

316.3484

Exact Mass：

316.35

HScode：

29095000

Characteristics

PSA：

57.2

XLogP3：

3.7

Appearance：

off-white

Density：

1.184±0.06 g/cm3(Predicted)

Melting Point：

116-117 °C @ Solvent: Ethyl acetate

Boiling Point：

490.3±45.0 °C(Predicted)

Flash Point：

250.3±28.7 °C

Refractive Index：

1.607

Water Solubility：

DMSO: >10mg/mL

Storage Conditions：

Desiccate at -20°C

Vapor Pressure：

3.09E-10mmHg at 25°C

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1

Transport codes：

UN 2811

wgk germany：

hazard class code：

23/24/25-41

safety instructions：

26-36/37-39-45

Marks：

Precautionary statement(s)：

P261-P280-P301 + P310-P305 + P351 + P338-P311

Hazard Statements：

H301 + H311 + H331-H318

Combretastatin A4 Use and Manufacturing

Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage.A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.

Recommended Suppliers of Combretastatin A4

Hainan Flying International Trade Co., L Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of vitamin

High Quality API powder Combretastatin A4 /117048-59-6 Combretastatin A4 99%

CAS No.: 117048-59-6

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Combretastatin A4

CAS No.: 117048-59-6

Content: 99.00%

Inquiry
Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

Combretastatin A4

CAS No.: 117048-59-6

Content: 99%

Inquiry
nschem Contact Supplier

CN
6 YRS

Business licensed Certified factory

Manufactory Supplier of Chloranil,Ascomycin,Gemcitabine,Levamlodipine,Isoflurane,1-(4-Pyridyl)acetone,Peramivir,SiO2,Aluminum oxide,Posaconazole Main Ring,Rapamycin,Clemastine fumarate,Tacrolimus,SiO,Milrinone,Benzyl alcohol,Isavuconazole intermediate,Clofarabine,Prasugrel,Daptomycin,hydroxyapatite,1,Atracurium oxalate,Atazanavir sulfate,Decitabine,Zirconium dioxide,5-Pentanediol diacrylate,Darunavir,Vorapaxar intermediate,Meloxicam,Carfilzomib,Miglitol,Isavuconazole

Combretastatin A4

CAS No.: 117048-59-6

Grade: Pharmaceutical Grade

Content: 98%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Combretastatin A4 CAS 117048-59-6

CAS No.: 117048-59-6

Grade: Pharmaceutical Grade

Content: 99%

Inquiry