CHROMAN-6-CARBALDEHYDE
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CHROMAN-6-CARBALDEHYDE
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CAS No:
55745-97-6
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Formula:
C10H10O2
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Chemical Name:
CHROMAN-6-CARBALDEHYDE
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Synonyms:
CHROMAN-6-CARBALDEHYDE;Chroman-6-carboxaldehyde;3,4-Dihydro-2H-chromene-6-carboxaldehyde;6-Chromanecarbaldehyde
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CAS No:
Safety Information
IRRITANT
52
Xi
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
CHROMAN-6-CARBALDEHYDE Use and Manufacturing
To a solution of chromane (LVI) (3 g, 22.4 mmol, 1.0 eq) and DMF (3.3 g, 45.2 mmol, 2 eq) in DCE (20 mL) was added phosphorus oxychloride (3.4 g, 45.2 mmol, 2 eq) dropwise over 30 min below 50° C. The mixture was stirred at 85° C. for 12 h. The reaction was quenched by water and extracted with EtOAc (3×300 mL). The combined organic phase was dried over anhydrous Na