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CIPROXIFAN

CIPROXIFAN structure

CAS No:
184025-19-2
Formula:
C16H18N2O2.C4H4O4
Chemical Name:
CIPROXIFAN
Synonyms:
Ciproxifan Moleate;FUB 359 Maleate;FUB359 Maleate;FUB-359 Maleate;Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt;Ciproxifan maleate, >=98%;(4-(3-(1H-Imidazol-5-yl)propoxy)phenyl)(cyclopropyl)methanone maleate;CIPROXIFAN

Description

Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.IC50 value: Target: H3 receptorIn vitro, Ciproxifan behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 re

CIPROXIFAN Basic Attributes

Molecular Weight：

386.402

Exact Mass：

386.147797

DSSTox ID：

DTXSID20585107

Characteristics

PSA：

129.58000

XLogP3：

2.72580

Appearance：

white to beige

Boiling Point：

743.6ºC at 760 mmHg

Flash Point：

403.5ºC

Water Solubility：

DMSO: soluble32mg/mL

Vapor Pressure：

3.22E-23mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38-43

safety instructions：

26-36/37/39

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H315-H317-H319-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

CIPROXIFAN Use and Manufacturing

Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders.

Computed Properties

Molecular Weight:386.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:386.14778643
Monoisotopic Mass:386.14778643
Topological Polar Surface Area:130
Heavy Atom Count:28
Complexity:441
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Ciproxifan Maleate

CAS No.: 184025-19-2

Content: 99.00%

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CAS No.: 184025-19-2

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Guide of CIPROXIFAN

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
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