1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol
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1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol
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CAS No:
58020-43-2
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Formula:
C12H18ClNO2
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Chemical Name:
1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol
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Synonyms:
1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol;4-Hydroxytulobuterol;Benzenemethanol,2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-;HOKU 81;2-Chloro-α-[(tert-butylamino)methyl]-4-hydroxybenzenemethanol;2-Chloro-alpha-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxybenzenemethanol
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CAS No:
Description
HOKU-81, a new bronchodilator, is one of the metabolites of tulobuterol. IC50 Value: Target: Adrenergic ReceptorEffects of HOKU-81 on isolated trachea and atria of guinea pigs were compared with those of various bronchodilators. HOKU-81 appears to be a potent and selective beta 2-stimulant with a slight inotropic action. HOKU-81 was approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effe
Computed Properties
Molecular Weight:243.73
XLogP3:1.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:243.1026065
Monoisotopic Mass:243.1026065
Topological Polar Surface Area:52.5
Heavy Atom Count:16
Complexity:218
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol
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