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(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone

(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone structure

CAS No:
215923-54-9
Formula:
C14H17NO3
Chemical Name:
(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
Synonyms:
Methanone,(2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinyl-;Piperidine,1-[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]-;(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone;CX 546;BDP 17;GR 87;1-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)piperidine;1-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)piperidine;205510-63-0

Description

CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.IC50 value:Target: AMPAR agonistin vitro: Treatments with the ampakine CX614 markedly and reversibly increased brain-derived neurotrophic factor (BDNF) mRNA and protein levels in cultured rat entorhinal/hippocampal slices [1]. in contrast to cyclothiazide or IDRA 21, the Ampakine CX546 binds specifically to the agonist bound nondesensitized receptor, most likely acting by destabilizing the desensitized recepto

(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone Basic Attributes

Molecular Weight：

247.29

Exact Mass：

247.29

UNII：

PV6YEC8983

DSSTox ID：

DTXSID70175951

HScode：

2934999090

Characteristics

PSA：

38.8

XLogP3：

1.1

Appearance：

white to off-white

Density：

1.215g/cm3

Boiling Point：

422.8°C at 760 mmHg

Flash Point：

209.5ºC

Refractive Index：

1.573

Water Solubility：

DMSO: ≥10mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

1-(1,4-benzodioxan-6-ylcarbonyl)piperidine

(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone Use and Manufacturing

It is one of a series of AMPA modulators matergic AMPA receptors.

Computed Properties

Molecular Weight:247.29
XLogP3:1.1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:247.12084340
Monoisotopic Mass:247.12084340
Topological Polar Surface Area:38.8
Heavy Atom Count:18
Complexity:301
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties

(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone

SDS

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