Erythromycin, cyclic 11,12-carbonate
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Erythromycin, cyclic 11,12-carbonate
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CAS No:
55224-05-0
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Formula:
C38H65NO14
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Chemical Name:
Erythromycin, cyclic 11,12-carbonate
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Synonyms:
Erythromycin,cyclic 11,12-carbonate;4H-1,3-Dioxolo[4,5-c]oxacyclotetradecin,erythromycin deriv.;Erythromycin A 11,12-carbonate;Davercin;Erythromycin A cyclic 11,12-carbonate;Erythromycin cyclic carbonate;11054-95-8;54365-46-7;58117-63-8;67186-98-5
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CAS No:
Description
Erythromycin Cyclocarbonate, derivative of Erythromycin, which is active against Gram-positive and some Gram-negative microorganisms.
Erythromycin, cyclic 11,12-carbonate Use and Manufacturing
Davercin (erythromycin A cyclic 11,12-carbonate) is a first generation semi-synthetic erythromycin. Davercin is prepared by coupling the 11- and 12-OH groups to form a cyclic carbonate. This simple modification improves the stability and hydrophobicity of the macrocyclic structure. Davercin shows comparable or better in vitro potency, low host toxicity and improved pharmacokinetics compared with erythromycin.
Drug Function and Efficacy
It belongs to the macrolide antibiotics. It acts on the 50S subunit of bacterial cell ribosomes and inhibits the synthesis of bacterial proteins. Cyclic erythromycin is a semi-synthetic derivative of erythromycin. The introduction of cyclic carbonate groups greatly improves the lipophilicity of erythromycin, thereby increasing its absorption. This structural change reduces the serum protein binding rate, improves the antibacterial activity and reduces toxicity.
Registered Holders
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Bright Future Pharmaceutical(Hainan) Co., Ltd.
Active
China
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Weizhi Pharmaceutical Co., Ltd.
Inactive
China
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China Resources Double-Crane Pharmaceutical Co., Ltd.
Inactive
China
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Erythromycin, cyclic 11,12-carbonate
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