Epidermal Growth Factor
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Epidermal Growth Factor
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CAS No:
62253-63-8
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Formula:
C270H401N73O83S7
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Chemical Name:
Epidermal Growth Factor
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Synonyms:
RECOMBINANT MOUSE EGF;RECOMBINANT HUMAN EGF;REC EPIDERMAL GROWTH FACTOR (HUMAN);REC EGF (HUMAN);RHEGF;MURINE URG;MURINE UROGASTRONE;MOUSE EGF
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CAS No:
Safety Information
NONH for all modes of transport
3
KB4518000
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
Computed Properties
Molecular Weight:6222
XLogP3:-17.3
Hydrogen Bond Donor Count:94
Hydrogen Bond Acceptor Count:98
Rotatable Bond Count:203
Exact Mass:6219.7513614
Monoisotopic Mass:6217.7446517
Topological Polar Surface Area:2550
Heavy Atom Count:433
Complexity:15800
Defined Atom Stereocenter Count:51
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Chemotaxis: Promote epithelial cells (epidermal cells, mucosal cells, endothelial cells), neutrophils, fibroblasts and other cells to migrate to the wound surface, provide a basis for tissue regeneration and repair, and shorten the wound healing time. Proliferation effect: ① Act on cell growth regulatory genes: Promote RNA and DNA replication and protein synthesis; ② Regulate cell glycolysis and Ca2 concentration; ③ Promote wound cell re-epithelialization and accelerate wound healing. Reconstruction effect: ① Promote the synthesis of extracellular matrix (hyaluronic acid, fibronectin, collagen, glycoprotein and hydroxyproline, etc.); ② Regulate the degradation and renewal of collagen and enhance the tensile strength of the wound surface; ③ Improve the complete regeneration and continuity of epithelial cells, prevent and reduce scar formation, and improve the quality of wound repair.
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