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Endoxifen

Endoxifen structure

CAS No:
112093-28-4
Formula:
C25H27NO2
Chemical Name:
Endoxifen
Synonyms:
Phenol,4-[(1Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-;Phenol,4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-,(Z)-;Phenol,4-[(1Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-;4-[(1Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol;4-Hydroxy-N-desmethyltamoxifen;Endoxifen;N-Desmethyl-4-hydroxytamoxifen;(Z)-Endoxifen
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Off-White to Pink Solid

Endoxifen Basic Attributes

Molecular Weight：

373.48738

Exact Mass：

373.49

Characteristics

PSA：

41.5

XLogP3：

5.75040

Density：

1.099±0.06 g/cm3(Predicted)

Melting Point：

139-143 °C

Boiling Point：

519.3±50.0 °C(Predicted)

Flash Point：

267.88ºC

Refractive Index：

1.599

Storage Conditions：

Amber Vial, -86°C Freezer, Under Inert Atmosphere

Vapor Pressure：

0mmHg at 25°C

Safety Information

Transport codes：

UN 3077 9 / PGIII

RTECS Number：

SL8285000

Precautionary statement(s)：

P273-P391

Hazard Statements：

H400

Endoxifen Use and Manufacturing

A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.

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Endoxifen

CAS No.: 112093-28-4

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