ETHYL (4-IODOBENZOYL)ACETATE

General procedure: A mixture of 1H-benzo[d]imidazol-2-amine (1.5 mmol), ethyl 3-oxo-3-phenylpropanoate (0.5 mmol) and CBr4 (1 mmol) in CH3CN (2 mmol) was stirred in 80 C in a tube under air atmosphere. TLCmonitored the end of the reaction. Then the mixture was cooled toroom temperature and saturated brine (100 mL) was poured intothe solution. The mixture was extracted with EtOAc (3 50 mL).The organic phase was combined and dried by anhydrous Na2SO4.Finally, the product was separated by flash chromatography onsilica gel (petroleum ether/EtOAc 3: 1) and obtained aftervacuum-rotary evaporation.

Reactant for:• ;Synthesis of trisubstituted pyrroles via rearrangement reactions catalyzed by Ir catalyst1• ;Preparation of biologically active molecules2,3,4

Molecular Weight:318.11
XLogP3:2.5
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:317.97529
Monoisotopic Mass:317.97529
Topological Polar Surface Area:43.4
Heavy Atom Count:15
Complexity:232
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes